TRPC4

Across TCGA patient cohorts, TRPC4 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC4-associated genes across cancer lineages are FOXO3a_pS318_S321, ACC1, and PDCD4. Each is linked with TRPC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRPC4-to-partner and partner-to-TRPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TRPC4-low versus TRPC4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC4→partner) and Y-score (partner→TRPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FOXO3a_pS318_S321 →	-0.227	-2.584	.001	.009	3	4
STAD	ACC1 →	+0.454	+2.828	.008	.001	3	3
STAD	PDCD4 →	-0.366	-2.807	.036	.003	3	3
COAD	PKC-a →	-0.305	-2.321	.009	.033	3	3
UCEC	ERK2 →	+0.133	+1.169	.016	.017	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.295	-1.222	.022	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

FOXO3a_pS318_S321 by TRPC4 expression — STAD

Explore this box plot interactively →