TRPC4

Across TCGA cell cohorts, TRPC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,678 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TRPC4-associated GO terms across cancer lineages are Neuroligin clustering involved in postsynaptic membrane assembly, Protein-containing complex disassembly, and Negative regulation of activation of membrane attack complex. Each is linked with TRPC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both TRPC4-to-partner and partner-to-TRPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuroligin clustering involved in postsynaptic membrane assembly grouped by TRPC4-low versus TRPC4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC4→partner) and Y-score (partner→TRPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.307	+0.703	<.001	.002	3	7
BREAST	Protein-containing complex disassembly →	+0.039	+0.618	.001	.008	3	7
SKIN	Negative regulation of activation of membrane attack complex →	+0.122	+0.488	.001	.006	3	7
SKIN	Thiamine transmembrane transport →	-0.896	-0.961	<.001	.002	3	7
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.096	+0.991	<.001	.002	3	7
STOMACH	Regulation of intracellular protein transport →	+0.051	+0.341	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,678 associations by consensus.

Neuroligin clustering involved in postsynaptic membrane assembly by TRPC4 expression — BREAST

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