TRPC4

Across TCGA cell cohorts, TRPC4 mutation is significantly associated with the RNA expression of many other genes, with 878 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPC4-associated genes across cancer lineages are OR8B12, TEX53, and AADACL3. Each is linked with TRPC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPC4-to-partner and partner-to-TRPC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by TRPC4-low versus TRPC4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC4→partner) and Y-score (partner→TRPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR8B12 →	+0.030	+4.369	<.001	.008	3	2
SOFT_TISSUE	TEX53 →	+0.098	+5.169	<.001	<.001	3	2
SKIN	AADACL3 →	+0.003	+2.977	<.001	.006	3	2
OVARY	USP17L17 →	+0.010	+4.807	<.001	.003	3	2
LUNG_NSCLC_LUAD	MYOG →	+0.011	+2.606	.004	.001	3	2
LUNG_NSCLC_LUAD	RESP18 →	+0.013	+2.555	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 878 associations by consensus.

OR8B12 by TRPC4 expression — SOFT_TISSUE

Explore this box plot interactively →