TRPC1

Across TCGA patient cohorts, TRPC1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPC1-associated genes across cancer lineages are Notch1, TIGAR, and Caspase-7-cleavedD198. Each is linked with TRPC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRPC1-to-partner and partner-to-TRPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TRPC1-low versus TRPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPC1→partner) and Y-score (partner→TRPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.112	+1.331	.016	.043	3	3
UCEC	TIGAR →	+0.166	+2.584	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.673	+2.434	<.001	.001	3	3
UCEC	FASN →	+0.289	+1.807	.026	.025	3	2
UCEC	FoxM1 →	+0.190	+1.652	.026	.006	3	2
UCEC	p62 Lck ligand →	+0.496	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Notch1 by TRPC1 expression — UCEC

Explore this box plot interactively →