TRPA1

Across TCGA patient cohorts, TRPA1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPA1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and CD31. Each is linked with TRPA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRPA1-to-partner and partner-to-TRPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TRPA1-low versus TRPA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPA1→partner) and Y-score (partner→TRPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.211	+2.000	.033	.028	3	5
UCEC	Cyclin-B1 →	+0.590	+3.087	<.001	<.001	3	4
STAD	CD31 →	-0.150	-2.584	.003	.008	3	3
STAD	c-Kit →	-0.303	-2.807	.003	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.894	<.001	.001	3	3
LUSC	cIAP →	+0.126	+1.331	.003	.044	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

4E-BP1 by TRPA1 expression — STAD

Explore this box plot interactively →