TRPA1

Across TCGA cell cohorts, TRPA1 mutation is significantly associated with the RNA expression of many other genes, with 478 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPA1-associated genes across cancer lineages are RTP1, OR1L3, and PGM3. Each is linked with TRPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRPA1-to-partner and partner-to-TRPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTP1 grouped by TRPA1-low versus TRPA1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPA1→partner) and Y-score (partner→TRPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RTP1 →	+0.025	+4.459	<.001	.001	3	2
OVARY	OR1L3 →	+0.037	+3.444	<.001	.003	3	2
LARGE_INTESTINE	PGM3 →	+0.918	+3.389	<.001	.001	3	2
LARGE_INTESTINE	RWDD2A →	+0.425	+2.588	.005	.004	3	2
LARGE_INTESTINE	TMEM31 →	+0.271	+3.295	.008	.003	3	2
LARGE_INTESTINE	EXOSC5 →	+0.492	+3.234	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 478 associations by consensus.

RTP1 by TRPA1 expression — LIVER

Explore this box plot interactively →