TRPA1

Across TCGA cell cohorts, TRPA1 mutation is significantly associated with the mutation status of many other genes, with 4,536 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRPA1-associated genes across cancer lineages are PTPRS, PLEC, and TRRAP. Each is linked with TRPA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRPA1-to-partner and partner-to-TRPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRS grouped by TRPA1-low versus TRPA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPA1→partner) and Y-score (partner→TRPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTPRS →	+4.467	+4.467	<.001	<.001	1	6
BREAST	PLEC →	+2.189	+3.777	.007	.007	1	6
OVARY	TRRAP →	+2.204	+2.791	.005	.005	1	6
BLOOD_Leukemia	PCDHA2 →	+3.235	+3.347	<.001	<.001	1	6
BLOOD_Lymphoma	SCN4A →	+4.260	+4.260	<.001	<.001	1	6
BLOOD_Lymphoma	ROBO1 →	+3.038	+3.611	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

PTPRS by TRPA1 expression — OVARY

Explore this box plot interactively →