TROAP

Across TCGA patient cohorts, TROAP mutation is significantly associated with the RNA expression of many other genes, with 1,317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TROAP-associated genes across cancer lineages are NMBR-AS1, SYPL1P1, and CDT1. Each is linked with TROAP in more than 2 cancer types. Because this analysis shows association rather than direction, both TROAP-to-partner and partner-to-TROAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NMBR-AS1 grouped by TROAP-low versus TROAP-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TROAP→partner) and Y-score (partner→TROAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NMBR-AS1 →	+0.135	+3.612	<.001	.006	3	3
COAD	SYPL1P1 →	+0.165	+5.693	<.001	.003	3	3
SKCM	CDT1 →	+0.848	+3.334	.001	.005	3	2
SKCM	FAM27E5 →	+0.082	+2.923	.001	.004	3	2
SKCM	MIR196A2 →	+0.321	+2.310	<.001	.007	3	2
SKCM	FANCG →	+0.586	+3.198	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,317 associations by consensus.

NMBR-AS1 by TROAP expression — CESC

Explore this box plot interactively →