TROAP

Across TCGA patient cohorts, TROAP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TROAP-associated genes across cancer lineages are Annexin-1, TIGAR, and MSH6. Each is linked with TROAP in more than 1 cancer types. Because this analysis shows association rather than direction, both TROAP-to-partner and partner-to-TROAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TROAP-low versus TROAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TROAP→partner) and Y-score (partner→TROAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.712	+3.479	.001	.002	3	2
UCEC	TIGAR →	+0.125	+1.833	.047	.016	3	2
LUSC	MSH6 →	+0.447	+3.179	.026	.010	2	2
LUSC	PREX1 →	-0.321	-3.160	<.001	.019	3	1
LUSC	Rab11 →	-0.193	-3.160	.002	.019	2	2
UCEC	eIF4E →	+0.200	+2.335	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Annexin-1 by TROAP expression — UCEC

Explore this box plot interactively →