TROAP

Across TCGA cell cohorts, TROAP mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TROAP-associated genes across cancer lineages are CDRT15L2, TAFA1, and NLRP2B. Each is linked with TROAP in more than 1 cancer types. Because this analysis shows association rather than direction, both TROAP-to-partner and partner-to-TROAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDRT15L2 grouped by TROAP-low versus TROAP-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TROAP→partner) and Y-score (partner→TROAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDRT15L2 →	+0.020	+4.807	<.001	.006	3	1
OVARY	TAFA1 →	+0.033	+4.078	.009	.003	3	1
OVARY	NLRP2B →	+0.048	+4.392	.002	.004	3	1
LARGE_INTESTINE	BCCIP →	+0.513	+3.212	.006	.006	3	1
LARGE_INTESTINE	COQ5 →	+0.621	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DPH5 →	+0.607	+3.212	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

CDRT15L2 by TROAP expression — BLOOD_Myeloma

Explore this box plot interactively →