TRO

Across TCGA patient cohorts, TRO mutation is significantly associated with the RNA expression of many other genes, with 6,211 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRO-associated genes across cancer lineages are BNIP3P3, FECH, and TIMM21. Each is linked with TRO in more than 3 cancer types. Because this analysis shows association rather than direction, both TRO-to-partner and partner-to-TRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P3 grouped by TRO-low versus TRO-high in UCS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRO→partner) and Y-score (partner→TRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	BNIP3P3 →	+0.166	+5.087	<.001	.006	3	4
SKCM	FECH →	+0.546	+2.913	.002	.001	3	4
COAD	TIMM21 →	+0.491	+3.486	<.001	.002	3	4
LUSC	MRPL41 →	+0.466	+2.462	.004	.001	3	4
UCEC	EIF5A →	+0.327	+1.584	<.001	<.001	3	4
UCEC	SKA1 →	+0.631	+2.061	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,211 associations by consensus.

BNIP3P3 by TRO expression — UCS

Explore this box plot interactively →