TRO

Across TCGA patient cohorts, TRO mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRO-associated genes across cancer lineages are FASN, FoxM1, and eIF4E. Each is linked with TRO in more than 3 cancer types. Because this analysis shows association rather than direction, both TRO-to-partner and partner-to-TRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TRO-low versus TRO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRO→partner) and Y-score (partner→TRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.504	+2.008	.001	.018	3	4
SKCM	FoxM1 →	+0.310	+3.169	.001	.017	3	4
UCEC	eIF4E →	+0.222	+1.616	<.001	<.001	3	3
STAD	ER-alpha →	-0.173	-2.563	.016	.010	3	3
STAD	PKC-delta_pS664 →	-0.131	-3.154	.020	.018	3	3
SKCM	Di-Ras3 →	-0.135	-3.169	.038	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

FASN by TRO expression — COAD

Explore this box plot interactively →