TRO

Across TCGA cell cohorts, TRO RNA expression is significantly associated with the go_rna of many other GO terms, with 3,854 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRO-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, DNA-templated transcription initiation, and Transcription initiation at RNA polymerase II promoter. Each is linked with TRO in more than 12 cancer types. Because this analysis shows association rather than direction, both TRO-to-partner and partner-to-TRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by TRO-low versus TRO-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRO→partner) and Y-score (partner→TRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of gene expression, epigenetic →	+0.072	+0.783	<.001	.008	3	13
STOMACH	DNA-templated transcription initiation →	+0.080	+1.410	<.001	.009	3	12
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.069	+0.900	<.001	.003	3	12
OVARY	Heterochromatin organization →	+0.060	+2.740	.001	<.001	3	12
BONE	Protein-DNA complex organization →	+0.087	+1.258	<.001	<.001	3	12
OVARY	Regulation of RNA splicing →	+0.081	+2.185	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,854 associations by consensus.

Negative regulation of gene expression, epigenetic by TRO expression — STOMACH

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