TRO

Across TCGA cell cohorts, TRO mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRO-associated genes across cancer lineages are OXT, BBOF1, and CHRNA4. Each is linked with TRO in more than 2 cancer types. Because this analysis shows association rather than direction, both TRO-to-partner and partner-to-TRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by TRO-low versus TRO-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRO→partner) and Y-score (partner→TRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OXT →	+0.185	+4.584	<.001	.001	3	2
LARGE_INTESTINE	BBOF1 →	+0.683	+3.628	.003	<.001	2	3
CNS	CHRNA4 →	+0.428	+3.144	<.001	.002	3	2
SKIN	DIO3 →	+0.226	+3.716	.004	.003	3	2
OVARY	CCR8 →	+0.127	+4.070	.001	.003	3	2
BLOOD_Leukemia	PCDH10 →	+1.290	+3.351	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

OXT by TRO expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →