TRMT61B

Across TCGA patient cohorts, TRMT61B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT61B-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and A-Raf_pS299. Each is linked with TRMT61B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT61B-to-partner and partner-to-TRMT61B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TRMT61B-low versus TRMT61B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT61B→partner) and Y-score (partner→TRMT61B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.220	-2.321	.044	.033	3	1
UCEC	eIF4G →	+0.389	+3.321	.004	.010	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.115	.025	.019	3	1
UCEC	Gab2 →	+0.409	+2.115	.008	.019	3	1
UCEC	MSH2 →	-0.254	-3.143	.011	.018	3	1
UCEC	mTOR_pS2448 →	-0.151	-2.115	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by TRMT61B expression — UCEC

Explore this box plot interactively →