TRMT61A

Across TCGA pan-cancer cohorts, TRMT61A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRMT61A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TRMT61A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRMT61A expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where TRMT61A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	1.000	0.614	<.001	46	view →
GBM	OS	Tertile	All	0.586	0.246	.002	29	view →
CCRCC	DFS	Tertile	II,III,IV	0.789	1.000	.005	28	view →
HNSC	DFS	Median	All	0.698	1.000	.020	26	view →
PDAC	DFS	Median	II,III,IV	0.299	0.506	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRMT61A–LSCC (OS)

Open the LSCC breakdown →