TRMT61A

Across TCGA patient cohorts, TRMT61A mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT61A-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Ku80, and p62 Lck ligand. Each is linked with TRMT61A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT61A-to-partner and partner-to-TRMT61A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by TRMT61A-low versus TRMT61A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT61A→partner) and Y-score (partner→TRMT61A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.575	+2.817	.014	.036	3	1
UCEC	Ku80 →	+0.358	+3.013	.005	.018	3	1
UCEC	p62 Lck ligand →	+0.358	+3.009	.045	.019	3	1
UCEC	AMPK_pT172 →	+0.476	+3.183	.035	.010	3	1
UCEC	Rab11 →	-0.219	-2.999	.005	.035	3	1
UCEC	ERK2 →	+0.233	+3.169	.027	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GSK-3a-b_pS21_S9 by TRMT61A expression — UCEC

Explore this box plot interactively →