TRMT6

Across TCGA patient cohorts, TRMT6 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT6-associated genes across cancer lineages are PCNA, EGFR_pY1068, and EGFR. Each is linked with TRMT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT6-to-partner and partner-to-TRMT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TRMT6-low versus TRMT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT6→partner) and Y-score (partner→TRMT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.237	+3.169	.005	.018	3	2
UCEC	EGFR_pY1068 →	-0.262	-1.584	.007	.036	3	1
UCEC	EGFR →	-0.167	-2.000	.007	.010	3	1
UCEC	FASN →	+0.330	+2.459	.032	.019	3	1
UCEC	FoxM1 →	+0.213	+3.331	.036	.005	3	1
UCEC	Ku80 →	+0.208	+1.598	.025	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PCNA by TRMT6 expression — UCEC

Explore this box plot interactively →