Across TCGA patient cohorts, TRMT2B mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT2B-associated genes across cancer lineages are c-Met_pY1235, 14-3-3_beta, and eEF2. Each is linked with TRMT2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT2B-to-partner and partner-to-TRMT2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT2B→partner) and Y-score (partner→TRMT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.068	+1.440	.008	.024	3	2
UCEC	14-3-3_beta →	-0.076	-3.295	.028	.009	3	1
UCEC	eEF2 →	+0.335	+2.115	.006	.017	3	1
UCEC	eIF4E →	+0.175	+1.736	.016	.007	3	1
UCEC	FOXO3a_pS318_S321 →	-0.102	-1.575	.018	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.807	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

TRMT2B survival (RNA) · tumor vs normal (RNA) · all TRMT2B data types