TRMT1L

Across TCGA cell cohorts, TRMT1L mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRMT1L-associated genes across cancer lineages are CLEC10A, MMP26, and PPDPFL. Each is linked with TRMT1L in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT1L-to-partner and partner-to-TRMT1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC10A grouped by TRMT1L-low versus TRMT1L-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT1L→partner) and Y-score (partner→TRMT1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLEC10A →	+0.019	+5.196	<.001	.005	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2C →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CLEC10A by TRMT1L expression — OVARY

Explore this box plot interactively →