Across TCGA pan-cancer cohorts, TRMT12 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRMT12 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRMT12 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRMT12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SKCM, and OV are the cancer types where TRMT12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.625	.008	18	view →
SKCM	OS	Median	All	0.230	0.781	.004	18	view →
OV	OS	Median	II,III,IV	0.324	0.691	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRMT12 tumor-vs-normal RNA expression · all TRMT12 data types