TRMT112

Across TCGA patient cohorts, TRMT112 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT112-associated genes across cancer lineages are C18orf12, GOLGA8F, and POTED. Each is linked with TRMT112 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT112-to-partner and partner-to-TRMT112 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf12 grouped by TRMT112-low versus TRMT112-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT112→partner) and Y-score (partner→TRMT112) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf12 →	+0.245	+4.146	.007	.003	3	1
UCEC	GOLGA8F →	+0.038	+4.078	<.001	.005	3	1
UCEC	POTED →	+0.017	+4.267	.004	.009	3	1
BLCA	ABHD17AP8 →	+0.095	+5.685	.002	.003	3	1
BLCA	SIGLEC21P →	+0.053	+6.289	<.001	.001	3	1
BLCA	MIR1273H →	+0.382	+4.973	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C18orf12 by TRMT112 expression — UCEC

Explore this box plot interactively →