TRMT10A

Across TCGA pan-cancer cohorts, TRMT10A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRMT10A data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRMT10A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRMT10A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where TRMT10A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.950	0.701	<.001	70	view →
UCEC	DFS	Median	III,IV	1.000	0.274	.002	38	view →
CCRCC	DFS	Median	All	0.729	0.893	.019	11	view →
LSCC	DFS	Quartile	II,III,IV	0.926	0.447	.007	11	view →
PDAC	OS	Tertile	IV	0.472	0.934	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRMT10A–HNSC (OS)

Open the HNSC breakdown →