TRMT10A

Across TCGA patient cohorts, TRMT10A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT10A-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with TRMT10A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT10A-to-partner and partner-to-TRMT10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRMT10A-low versus TRMT10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT10A→partner) and Y-score (partner→TRMT10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.617	-3.571	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.833	+1.894	<.001	.030	3	2
UCEC	4E-BP1 →	+0.403	+2.614	<.001	.005	3	2
UCEC	eEF2 →	+0.397	+2.999	.005	.035	3	1
UCEC	EGFR_pY1068 →	-0.313	-3.087	.001	<.001	3	1
UCEC	ERK2 →	+0.178	+2.321	.021	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by TRMT10A expression — UCEC

Explore this box plot interactively →