TRMT1

Across TCGA patient cohorts, TRMT1 mutation is significantly associated with the RNA expression of many other genes, with 1,624 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT1-associated genes across cancer lineages are KRT18P44, MYG1, and SRIP3. Each is linked with TRMT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRMT1-to-partner and partner-to-TRMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT18P44 grouped by TRMT1-low versus TRMT1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT1→partner) and Y-score (partner→TRMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KRT18P44 →	+0.050	+4.086	.004	.005	3	3
SKCM	MYG1 →	+0.510	+3.604	<.001	.001	3	3
UCEC	SRIP3 →	+0.398	+1.725	.001	.007	3	3
BLCA	RPL21P33 →	+0.233	+3.016	.005	.005	3	3
BLCA	RN7SL571P →	+0.102	+4.455	<.001	.005	3	3
SKCM	ITFG2-AS1 →	+0.407	+3.220	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,624 associations by consensus.

KRT18P44 by TRMT1 expression — LUSC

Explore this box plot interactively →