TRMT1

Across TCGA patient cohorts, TRMT1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRMT1-associated genes across cancer lineages are FoxM1, PR, and Stathmin. Each is linked with TRMT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRMT1-to-partner and partner-to-TRMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TRMT1-low versus TRMT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT1→partner) and Y-score (partner→TRMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.390	+3.169	<.001	.019	3	3
UCEC	PR →	-0.202	-3.169	.040	.018	3	2
UCEC	Stathmin →	+0.135	+2.000	.012	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.880	+3.321	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.121	-2.432	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.231	-2.000	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FoxM1 by TRMT1 expression — SKCM

Explore this box plot interactively →