TRMT1

Across TCGA cell cohorts, TRMT1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRMT1-associated genes across cancer lineages are RESP18, KCNK18, and EPPIN. Each is linked with TRMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRMT1-to-partner and partner-to-TRMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RESP18 grouped by TRMT1-low versus TRMT1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRMT1→partner) and Y-score (partner→TRMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RESP18 →	+0.040	+5.285	<.001	.003	3	1
STOMACH	KCNK18 →	+0.020	+5.285	<.001	.003	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR10G3 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	C14orf177 →	+0.100	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RESP18 by TRMT1 expression — STOMACH

Explore this box plot interactively →