TRIT1

Across TCGA patient cohorts, TRIT1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIT1-associated genes across cancer lineages are mTOR_pS2448, MSH2, and PDK1. Each is linked with TRIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIT1-to-partner and partner-to-TRIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TRIT1-low versus TRIT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIT1→partner) and Y-score (partner→TRIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.191	-2.321	.010	.035	3	2
UCEC	MSH2 →	-0.442	-3.143	<.001	.018	3	1
UCEC	PDK1 →	+0.113	+2.321	.037	.035	3	1
UCEC	STAT3_pY705 →	-0.469	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.781	-2.986	<.001	.035	3	1
UCEC	Bcl-2 →	-0.426	-2.295	.014	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

mTOR_pS2448 by TRIT1 expression — UCEC

Explore this box plot interactively →