TRIR

Across TCGA pan-cancer cohorts, TRIR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TRIR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRIR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIR is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where TRIR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.494	<.001	12	view →
COAD	Female	II,III,IV	+0.704	<.001	11	view →
HNSC	Male	III,IV	+0.796	<.001	10	view →
LIHC	All	II,III,IV	+0.533	<.001	7	view →
UCEC	All	All	+0.396	.002	6	view →
KICH	All	All	−0.602	<.001	5	view →
STAD	All	All	+0.487	.001	5	view →
LUAD	All	All	−0.249	<.001	5	view →
BRCA	All	All	+0.152	.009	4	view →
CHOL	All	All	+1.177	<.001	2	view →
ESCA	All	All	+0.836	<.001	2	view →
LUSC	All	II,III,IV	+0.261	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TRIR–KIRC

Open the KIRC breakdown →