TRIP4

Across TCGA patient cohorts, TRIP4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP4-associated genes across cancer lineages are MEK1, PR, and TFRC. Each is linked with TRIP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP4-to-partner and partner-to-TRIP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TRIP4-low versus TRIP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP4→partner) and Y-score (partner→TRIP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.443	+3.700	.004	.001	3	2
UCEC	PR →	-0.237	-3.169	.026	.019	3	2
UCEC	TFRC →	+0.633	+2.999	.004	.035	3	2
UCEC	ASNS →	+0.658	+2.584	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.119	-2.432	.005	.018	3	1
UCEC	eIF4E →	+0.220	+2.906	.013	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by TRIP4 expression — UCEC

Explore this box plot interactively →