TRIP4

Across TCGA cell cohorts, TRIP4 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIP4-associated genes across cancer lineages are GALP, MYPN, and SLC18A3. Each is linked with TRIP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP4-to-partner and partner-to-TRIP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by TRIP4-low versus TRIP4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP4→partner) and Y-score (partner→TRIP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
BLOOD_Leukemia	MYPN →	+0.037	+4.152	<.001	.009	3	1
BLOOD_Leukemia	SLC18A3 →	+0.016	+4.276	<.001	.007	3	1
BLOOD_Leukemia	TEX50 →	+0.029	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TEX13A →	+0.049	+4.969	<.001	.003	3	1
STOMACH	OR1E3 →	+0.250	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GALP by TRIP4 expression — SKIN

Explore this box plot interactively →