TRIP13

Across TCGA patient cohorts, TRIP13 mutation is significantly associated with the RNA expression of many other genes, with 2,449 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP13-associated genes across cancer lineages are RN7SL440P, CDKN3, and SNX8. Each is linked with TRIP13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP13-to-partner and partner-to-TRIP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL440P grouped by TRIP13-low versus TRIP13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP13→partner) and Y-score (partner→TRIP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL440P →	+0.107	+2.174	<.001	.008	3	2
UCEC	CDKN3 →	+0.870	+3.180	<.001	<.001	3	2
UCEC	SNX8 →	+0.544	+2.513	<.001	.001	3	2
UCEC	PLEKHM2 →	+0.413	+2.545	.002	.001	3	2
UCEC	EEF2KMT →	+0.513	+2.523	<.001	.001	3	2
UCEC	RNFT2 →	+0.534	+3.343	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,449 associations by consensus.

RN7SL440P by TRIP13 expression — UCEC

Explore this box plot interactively →