TRIP13

Across TCGA patient cohorts, TRIP13 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP13-associated genes across cancer lineages are eIF4G, ERK2, and FOXO3a_pS318_S321. Each is linked with TRIP13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP13-to-partner and partner-to-TRIP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TRIP13-low versus TRIP13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP13→partner) and Y-score (partner→TRIP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.264	+2.999	.044	.035	3	1
UCEC	ERK2 →	+0.174	+2.459	.033	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.700	.027	.044	3	1
UCEC	GAPDH →	+0.569	+2.321	.012	.033	3	1
UCEC	HER3 →	+0.388	+2.820	<.001	.035	3	1
UCEC	JNK2 →	+0.254	+3.026	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4G by TRIP13 expression — UCEC

Explore this box plot interactively →