TRIP13

Across TCGA cell cohorts, TRIP13 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,130 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIP13-associated GO terms across cancer lineages are Positive regulation of cell cycle process, Nuclear chromosome segregation, and Nuclear division. Each is linked with TRIP13 in more than 18 cancer types. Because this analysis shows association rather than direction, both TRIP13-to-partner and partner-to-TRIP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle process grouped by TRIP13-low versus TRIP13-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP13→partner) and Y-score (partner→TRIP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle process →	+0.125	+2.128	<.001	<.001	3	19
OESOPHAGUS	Nuclear chromosome segregation →	+0.151	+2.003	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.124	+2.144	<.001	<.001	3	19
OESOPHAGUS	Mitotic spindle assembly checkpoint signaling →	+0.177	+1.653	.002	.004	3	18
OESOPHAGUS	Spindle assembly checkpoint signaling →	+0.177	+1.653	.002	.004	3	18
OESOPHAGUS	Mitotic spindle checkpoint signaling →	+0.177	+1.653	.002	.004	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,130 associations by consensus.

Positive regulation of cell cycle process by TRIP13 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →