TRIP13

Across TCGA cell cohorts, TRIP13 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIP13-associated genes across cancer lineages are Mirin, Trametinib, and 741909. Each is linked with TRIP13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP13-to-partner and partner-to-TRIP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by TRIP13-low versus TRIP13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP13→partner) and Y-score (partner→TRIP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.531	+2.868	.002	.022	3	1
LARGE_INTESTINE	Trametinib →	-0.673	-2.745	.032	.047	3	1
LARGE_INTESTINE	741909 →	+0.732	+2.871	.002	.021	3	1
LARGE_INTESTINE	CI-1033 →	+0.726	+2.874	.010	.021	3	1
LARGE_INTESTINE	PF-00299804 →	+0.678	+2.874	.001	.021	3	1
LARGE_INTESTINE	Cytarabine →	+0.973	+2.655	.011	.044	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Mirin by TRIP13 expression — LARGE_INTESTINE

Explore this box plot interactively →