TRIP11

Across TCGA patient cohorts, TRIP11 mutation is significantly associated with the RNA expression of many other genes, with 4,413 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP11-associated genes across cancer lineages are GBGT1, GRXCR2, and RNU2-24P. Each is linked with TRIP11 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIP11-to-partner and partner-to-TRIP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBGT1 grouped by TRIP11-low versus TRIP11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP11→partner) and Y-score (partner→TRIP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GBGT1 →	-0.788	-3.687	<.001	.001	3	4
LUAD	GRXCR2 →	+0.131	+3.513	<.001	.002	3	3
READ	RNU2-24P →	+0.360	+3.827	<.001	.006	3	3
LUAD	OR10G6 →	+0.052	+4.418	<.001	.006	3	3
LUAD	MIR8053 →	+0.413	+3.928	<.001	.002	3	3
UCEC	UQCRC1 →	+0.320	+1.981	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,413 associations by consensus.

GBGT1 by TRIP11 expression — SKCM

Explore this box plot interactively →