TRIP11

Across TCGA cell cohorts, TRIP11 mutation is significantly associated with the RNA expression of many other genes, with 468 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIP11-associated genes across cancer lineages are HES3, IQCF5, and MAGEB4. Each is linked with TRIP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP11-to-partner and partner-to-TRIP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HES3 grouped by TRIP11-low versus TRIP11-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP11→partner) and Y-score (partner→TRIP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	2
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.000	<.001	.003	3	2
LARGE_INTESTINE	NRTN →	+0.707	+3.064	.007	.009	3	2
LARGE_INTESTINE	ZNF48 →	+0.517	+3.364	.006	.002	3	2
LIVER	CCL21 →	+0.032	+3.459	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 468 associations by consensus.

HES3 by TRIP11 expression — CNS

Explore this box plot interactively →