TRIP10

Across TCGA patient cohorts, TRIP10 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIP10-associated genes across cancer lineages are mTOR_pS2448, Src_pY416, and ATM. Each is linked with TRIP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIP10-to-partner and partner-to-TRIP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TRIP10-low versus TRIP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP10→partner) and Y-score (partner→TRIP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.134	-2.202	.018	.010	3	2
UCEC	Src_pY416 →	-0.225	-2.074	.014	.005	3	2
UCEC	ATM →	-0.359	-2.087	.039	.005	3	2
UCEC	Bad_pS112 →	-0.159	-1.678	.026	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.706	+1.926	.001	.008	3	2
UCEC	eIF4E →	+0.204	+3.700	.011	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

mTOR_pS2448 by TRIP10 expression — UCEC

Explore this box plot interactively →