TRIO

Across TCGA patient cohorts, TRIO protein abundance is significantly associated with the RNA expression of many other genes, with 10,849 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TRIO-associated genes across cancer lineages are BEND6, FILIP1L, and FAP. Each is linked with TRIO in more than 6 cancer types. Because this analysis shows association rather than direction, both TRIO-to-partner and partner-to-TRIO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRIO versus BEND6 in LUAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIO→partner) and Y-score (partner→TRIO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BEND6 →	+0.699	+0.396	<.001	<.001	3	7
UCEC	FILIP1L →	+0.725	+0.239	<.001	<.001	3	7
HNSC	FAP →	+1.328	+0.307	<.001	<.001	3	7
HNSC	CCDC127 →	+0.547	+0.247	<.001	<.001	3	7
UCEC	BEAN1 →	+0.548	+0.271	<.001	<.001	3	7
COAD	CALD1 →	+0.838	+0.203	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,849 associations by consensus.

TRIO vs BEND6 — LUAD

Explore this scatter interactively →