TRIO

Across TCGA patient cohorts, TRIO mutation is significantly associated with the RNA expression of many other genes, with 6,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIO-associated genes across cancer lineages are SNRPA, CXCL9, and PUS1. Each is linked with TRIO in more than 6 cancer types. Because this analysis shows association rather than direction, both TRIO-to-partner and partner-to-TRIO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPA grouped by TRIO-low versus TRIO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIO→partner) and Y-score (partner→TRIO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPA →	+0.297	+1.198	<.001	<.001	3	7
UCEC	CXCL9 →	+1.638	+1.662	<.001	<.001	3	5
BLCA	PUS1 →	+0.361	+1.670	.001	.007	3	5
STAD	TOMM40 →	+0.584	+3.016	.002	<.001	3	5
LUAD	BLOC1S3 →	+0.473	+2.642	<.001	.005	3	5
COAD	GZMH →	+1.005	+3.807	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,393 associations by consensus.

SNRPA by TRIO expression — UCEC

Explore this box plot interactively →