TRIO

Across TCGA patient cohorts, TRIO mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIO-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and PDK1_pS241. Each is linked with TRIO in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIO-to-partner and partner-to-TRIO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIO-low versus TRIO-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIO→partner) and Y-score (partner→TRIO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.108	+2.745	<.001	<.001	3	4
STAD	Cyclin-E2 →	+0.152	+1.758	.005	.045	3	3
BLCA	PDK1_pS241 →	-0.141	-2.446	.034	.018	3	3
BRCA	ERK2 →	+0.289	+2.817	.021	.037	3	3
COAD	ATM →	-0.443	-2.239	<.001	.001	3	3
COAD	AMPK_alpha →	-0.136	-1.805	.023	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

Caspase-7-cleavedD198 by TRIO expression — COAD

Explore this box plot interactively →