TRIO

Across TCGA cell cohorts, TRIO mutation is significantly associated with the RNA expression of many other genes, with 1,222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIO-associated genes across cancer lineages are OR2V1, POMK, and KCNJ11. Each is linked with TRIO in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIO-to-partner and partner-to-TRIO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2V1 grouped by TRIO-low versus TRIO-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIO→partner) and Y-score (partner→TRIO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2V1 →	+0.329	+2.440	.003	.009	3	3
BLOOD_Leukemia	POMK →	+0.758	+3.730	.005	<.001	3	3
LARGE_INTESTINE	KCNJ11 →	+0.591	+2.115	.002	.004	3	3
SOFT_TISSUE	APOA5 →	+0.061	+4.199	<.001	<.001	3	2
BLOOD_Leukemia	CYP26C1 →	+0.036	+2.310	.002	.005	3	2
BLOOD_Myeloma	FAM205A →	+0.024	+3.544	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,222 associations by consensus.

OR2V1 by TRIO expression — BLOOD_Lymphoma

Explore this box plot interactively →