TRIML2

Across TCGA pan-cancer cohorts, TRIML2 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated TRIML2 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRIML2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIML2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, ESCA, and COAD are the cancer types where TRIML2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.440	.020	24	view →
ESCA	DFS	Median	II,III,IV	0.128	0.529	<.001	21	view →
COAD	DFS	Median	II,III,IV	0.143	0.687	.003	17	view →
CESC	OS	Median	All	0.110	0.593	.002	12	view →
SARC	DFS	Median	All	0.130	0.617	<.001	12	view →
LUAD	OS	Median	III,IV	0.250	0.687	.006	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	OS	Median	All	0.176	0.724	.018	6	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
READ	DFS	Median	III,IV	0.269	0.744	.025	3	view →
SKCM	DFS	Median	II,III,IV	0.868	0.657	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TRIML2–UCEC (DFS)

Open the UCEC breakdown →