TRIM9

Across TCGA patient cohorts, TRIM9 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM9-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and TFRC. Each is linked with TRIM9 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM9-to-partner and partner-to-TRIM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIM9-low versus TRIM9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM9→partner) and Y-score (partner→TRIM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.741	+1.882	.025	.031	3	3
UCEC	PCNA →	+0.245	+1.736	<.001	<.001	3	3
UCEC	TFRC →	+0.392	+0.999	.010	.042	3	3
UCEC	Bak →	+0.176	+1.514	.014	.012	3	3
UCEC	Cyclin-B1 →	+0.717	+3.392	<.001	<.001	3	3
COAD	GSK-3_pS9 →	-0.330	-2.321	.043	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by TRIM9 expression — COAD

Explore this box plot interactively →