TRIM8

Across TCGA pan-cancer cohorts, TRIM8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRIM8 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM8 expression acts as an unfavorable survival marker.

LUAD, PRAD, and UCEC are the cancer types where TRIM8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.068	0.680	<.001	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TRIM8–LUAD (OS)

Open the LUAD breakdown →