TRIM8

Across TCGA patient cohorts, TRIM8 mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM8-associated genes across cancer lineages are RNU6-414P, TRAJ34, and TRAJ23. Each is linked with TRIM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM8-to-partner and partner-to-TRIM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-414P grouped by TRIM8-low versus TRIM8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM8→partner) and Y-score (partner→TRIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-414P →	+0.582	+3.169	.001	.004	3	2
COAD	TRAJ34 →	+0.603	+2.830	.007	.009	3	2
COAD	TRAJ23 →	+0.820	+3.361	.002	.001	3	2
COAD	TRAJ5 →	+1.562	+3.627	<.001	<.001	3	2
UCEC	NOCT →	+0.628	+2.010	<.001	.006	3	2
UCEC	EOGT →	+0.567	+2.021	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

RNU6-414P by TRIM8 expression — COAD

Explore this box plot interactively →