TRIM8

Across TCGA patient cohorts, TRIM8 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM8-associated genes across cancer lineages are Astrocytes, Macrophages, and Macrophages M1. Each is linked with TRIM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM8-to-partner and partner-to-TRIM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by TRIM8-low versus TRIM8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM8→partner) and Y-score (partner→TRIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Astrocytes →	+0.050	+3.692	.002	<.001	3	2
COAD	Macrophages →	+0.025	+3.288	.001	.002	3	1
COAD	Macrophages M1 →	+0.034	+2.832	<.001	.049	3	1
UCEC	mv Endothelial cells →	-0.019	-2.947	.034	.036	3	1
UCEC	Myocytes →	+0.035	+2.535	.005	.009	3	1
UCEC	CLP →	-0.068	-1.957	.005	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Astrocytes by TRIM8 expression — COAD

Explore this box plot interactively →