TRIM8

Across TCGA cell cohorts, TRIM8 mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM8-associated genes across cancer lineages are AVP, MAGEB4, and S100G. Each is linked with TRIM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM8-to-partner and partner-to-TRIM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by TRIM8-low versus TRIM8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM8→partner) and Y-score (partner→TRIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	S100G →	+1.369	+3.688	<.001	.002	3	1
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
BLOOD_Leukemia	PRORP →	+0.636	+3.199	.006	.007	3	1
BLOOD_Leukemia	SLC32A1 →	+0.578	+3.449	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

AVP by TRIM8 expression — LARGE_INTESTINE

Explore this box plot interactively →