TRIM74

Across TCGA pan-cancer cohorts, TRIM74 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM74 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher TRIM74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM74 expression acts as an unfavorable survival marker.

READ, BLCA, and COAD are the cancer types where TRIM74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.198	0.822	<.001	36	view →
BLCA	DFS	Median	All	0.077	0.626	<.001	27	view →
COAD	OS	Median	All	0.001	0.871	<.001	24	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
STAD	DFS	Median	All	0.211	0.709	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM74–READ (OS)

Open the READ breakdown →