TRIM73

Across TCGA patient cohorts, TRIM73 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM73-associated genes across cancer lineages are Lck, Notch1, and SF2. Each is linked with TRIM73 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM73-to-partner and partner-to-TRIM73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by TRIM73-low versus TRIM73-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM73→partner) and Y-score (partner→TRIM73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.409	+3.000	<.001	.037	3	2
UCEC	Notch1 →	+0.225	+2.820	.005	.035	3	1
UCEC	SF2 →	-0.151	-2.986	.017	.037	3	1
UCEC	DJ-1 →	+0.201	+3.000	.036	.037	3	1
UCEC	Shc_pY317 →	-0.200	-3.000	.022	.037	2	1
UCEC	MAPK_pT202_Y204 →	-0.541	-3.000	.046	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Lck by TRIM73 expression — UCEC

Explore this box plot interactively →